Arizona State University Biodesign Institute researcher Hao Yan has been named to Fast Company’s list of “Most Creative People in Business 2019” for his work using nanobots to fight cancerous tumors by choking off their blood supply.
Fast Company recognized Yan’s work using nanorobots to treat cancer at the molecular level. A pioneer in the field of DNA origami, Yan and his team in the Biodesign Center for Molecular Design and Biomimetics draw their inspiration from nature, seeking to solve complex human problems.
The magazine’s annual list seeks to highlight individuals across a wide range of fields, who “have accomplished something over the past year that has moved an entire industry forward in an unprecedented Yan is among a highly diverse group of people recognized, including actress Michelle Pfeiffer, late night talk show host Seth Meyers, athletes, activists and artists.
“I’m very honored to be included on this list,” said Yan, the Milton Glick Professor in the School of Molecular Sciences. “I am a scientist. I don’t think of myself as a business person.” Despite his science-first focus, Yan’s entrepreneurial spirit led him to launch Nanobot Biosciences, an early stage start-up that is poised to move his technology into commercial use. Yan hopes to begin to be able to treat human cancer patients within the next five years.
Fast Company focused on Yan’s work in building robots that are “one-thousandth the width of a strand of hair – and “constructed from DNA folded into 3D shapes.” The nanorobots are programmed to shrink tumors by finding the source of blood supply to the tumor and stopping that supply. Highly significant in this advance is that it does not affect the healthy cells – a conundrum in the world of cancer care with treatments like chemotherapy and radiation therapy. According to Fast Company, this “unique form of nanostructure technology has shown promise in initial tests, doubling the survival rate of mice with cancer.”
Yan attributes his ability to think creatively in part to nature, ASU President Michael Crow, and being housed in a highly interdisciplinary research environment at ASU’s Biodesign Institute.
“President Crow is someone I truly admire. He is always thinking outside the box,” said Yan. Yan explains that being at ASU means he is unconstrained by traditional boundaries and has freedom to take risks. Yan believes that perfection can sometimes be the enemy of creativity.
“The world comes with a lot of perfectionism,” said Yan. “While I have a habit to think deep and dig deeper, I can’t be creative if I am always trying to find the perfect answer. Looking around, it is simply not a perfect world, we need to find creative solutions for unmet challenges and be willing to take risks”.
"Professor Yan is an outstanding researcher who is constantly innovating to address grand challenges in health through an interdisciplinary approach,” says Sethuraman Panchanathan, executive vice president, ASU Knowledge Enterprise and chief research and innovation officer. “His work exemplifies the spirit of creativity that has the potential for global impact. He richly deserves this recognition.”
Yan also takes pride in creating an atmosphere where up-and-coming scientists can thrive. “I throw them in the pond and let them swim. I don’t want to produce a technician. I want to produce a creative thinker and a scientist who can come up with their own ideas and solve problems on their own.” Testament to that approach is the fact that Yan’s lab boasts three researchers who have been named “New Innovator” by the National Institutes of Health. He considers identifying promising scientists as one of his most creative acts.
“Creativity and courage are at the crux of good science,” said Joshua LaBaer, Biodesign Institute executive director. “Hao’s work inspires us all. He is representative of the intellectual curiosity that drives our organization – and most certainly, the spirit of innovation that is fostered and encouraged throughout Arizona State University.”
“The environment at Biodesign Institute really provides a space for people to easily reach out to so many different disciplines,” said Yan. He appreciates the ability to keep learning from others. “I didn’t know about tumor biology or cancer immunotherapy before, but now due to my colleagues here, I can merge my knowledge with theirs. I am always learning.”
Asked what he would do if he wasn’t a scientist, he said, “I would be a rock star, playing electric guitar and singing on stage.”
Yan’s honor comes a few years after another ASU luminary was named to the magazine’s 2015 Most Creative People,” Charles Arntzen. Arntzen, a co-founder of the Biodesign Institute, was recognized for his leadership role in developing ZMapp, a therapeutic to fight Ebola, produced in tobacco plants. China’s National Center for Nanoscience and Technology is a partner in Yan’s work.